Team Asprey

1044. How & Why You Age, And What It Takes To Be ‘Young Forever’

EPISODE #1044

How & Why You Age, And What It Takes To Be ‘Young Forever’

Mark Hyman, M.D.

Learn the Top 10 hallmarks of aging, the role of functional medicine in restoring and reversing aging, and the many practical ways you can promote your own longevity.

Mark_Hyman_2023

In this Episode of The Human Upgrade™...

… Mark Hyman, M.D., joins Dave in Austin to talk all things longevity. Driven by his desire for a healthier, longer life for himself and others, Dr. Mark immersed himself in the latest scientific research on aging and longevity. Through his findings, he realized that the body has an incredible built-in healing system that can be activated through understanding the emerging science of longevity. He also managed to reduce his biological age by 20 years effectively.

“I want my physiology and my body’s capacity to be getting better as I get older, and matching the wisdom and increased understanding of the world that happens as you get older,” Dr. Mark says.

He consistently tackles the topic of inflammation and its impact on aging—or “Inflammaging” as he calls it. “The body only has so many ways to say ouch,” Dr. Mark says. “You have pain. You have inflammation. You have certain things that happen that create all these symptoms, but there’re these common roots. So, inflammation is this common root that seems to accelerate as we get older. So, we can measure biomarkers of inflammation that are highly predictive of mortality.”

This conversation covers many components of aging, like metabolic flexibility and resilience, mTor, meat- and plant-based protein, nutrition, environmental allergies and food sensitivities, histamine, autophagy, fasting, DEXA scans, and much more!

“Diet, exercise, certain lifestyle practices, and certain supplements—and even certain medication can be useful,” Dr. Mark says about changing your health. In “Young Forever: The Secrets to Living Your Longest, Healthiest Life,” he:

  • shares the knowledge of how to unlock the causes of accelerated aging and treat it as a reversible disease.
  • gives you practical tips for daily habits that will increase your energy and performance.
  • teaches you why you age and what it really takes to live a longer, more vibrant life.

“At 63, I’m riding my bike and being faster than most of my 30, 40-year-old friends, and who basically can’t keep up with me,” he says about his own aging evolution. “The body has that capacity if you understand how to work with it. It’s never too late to start.”

Dr. Mark’s a practicing family physician and an internationally recognized leader, speaker, educator, and advocate in the field of Functional Medicine. He’s also a 15-time New York Times best-selling author and repeat guest on the show to share his broad knowledge and wisdom. Check out his other podcast conversations with Dave in the “Links & Resources” below.

Watch this episode on YouTube

“Health is about metabolic flexibility and resilience. Most of us are metabolically inflexible and metabolically not resilient.”

Mark Hyman, M.D.

Enjoy the show!

LISTEN: “Follow” or “subscribe” to The Human Upgrade™ with Dave Asprey on your favorite podcast platform.

REVIEW: Go to Apple Podcasts at daveasprey.com/apple and leave a (hopefully) 5-star rating and a creative review.

FEEDBACK: Got a comment, idea or question for the podcast? Submit via this form!

SOCIAL: Follow @thehumanupgradepodcast on Instagram and Facebook.

JOIN: Learn directly from Dave Asprey alongside others in a membership group: ourupgradecollective.com.

  • Our Partners
  • Links & Resources
  • Key Notes

Sleep Solutions for High Performance: https://sleepbreakthrough.com/dave, use code DAVE10 to get an extra 10% off

Join us at the 9th Annual Biohacking Conference: https://biohackingconference.com

Dave Asprey’s NEW Book! “Smarter Not Harder: The Biohacker’s Guide to Getting the Body and Mind You Want” https://daveasprey.com/books/

  • The difference between biological age and chronological age and how applying principles of functional medicine can help optimize biological age and avoid rapid aging.
  • The idea of aging as a treatable disease and how Dr. Hyman’s functional medicine approach focuses on restoring function and health, leading to disease reversal.
  • The hallmarks of aging and how they are interconnected systems.
  • The role of functional medicine in restoring and optimizing the function of biological systems, including mitochondrial function, immune regulation, microbiome, and nutrient regulation.
  • How functional medicine allows for the treatment of the root causes of diseases rather than just treating the hallmarks with drugs.
  • How deregulated nutrient sensing is a meta hallmark, influencing all other hallmarks.
  • The importance of a low glycemic diet to combat high levels of sugar and starch that contribute to obesity, heart disease, cancer, diabetes, and dementia.
  • The mTOR pathway and the importance of giving the pathway a rest to activate autophagy, the recycling and regeneration mode. 
  • The sirtuin pathway and its role in DNA repair and mitochondrial function. 
  • The potential drawbacks of weight loss medication, specifically the drug Ozempic.
  • How fasting and calorie restriction can activate the body’s repair systems and extend life by a third… but it can also be miserable. 
  • The benefits of the drug Rapamycin, which inhibits mTOR and activates processes such as autophagy and DNA repair. 
  • How to properly activate mTOR for protein synthesis, which is key for building muscle. 
  • Challenging the recommended dietary allowance (RDA) for protein, which is a minimum amount to avoid protein malnutrition.
  • Dr. Hyman’s perspective on healthy aging and optimal aging.
  • What “inflammaging” is and why it is the primary driver of all the diseases of aging, such as heart disease, cancer, diabetes, Alzheimer’s, and autoimmune disease. 
  • The discovery of four highly predictive inflammatory markers that are more effective than commonly measured markers. 
  • The role of mast cells in inflammation and the importance of reprogramming immune sensitivity. 
  • All about Dr. Hyman’s “Young Forever” book.

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Champion Insights from the Octagon: How to Train & Recover, Be a Parent, and Run a Business – Miesha Tate – #1034

EPISODE #1034

Champion Insights from the Octagon: How to Train & Recover, Be a Parent, and Run a Business

Miesha Tate

Learn the drive and discipline secrets of high-performance training, why mindset matters, the how the body follows the mind.

Miesha_Tate-2

In this Episode of The Human Upgrade™...

… you’ll learn why many professional athletes, especially fighters, are some of the top biohackers in the world. They hack their bodies, minds, and environments to achieve an incredibly high level of performance. Every hack they do has to be effective—and means the difference between winning and losing.

Professional MMA (mixed martial arts) fighter Miesha Tate knows and does just that while adding being a parent and entrepreneur into the mix. Miesha is a former UFC and Strikeforce Bantamweight champion, ONE Championship vice president, and winner of Celebrity Big Brother Season 3. She always draws on her experiences, whether from home birth or competing on the world’s biggest stages as a pro athlete as proof that when the mind and body are functioning with synchronicity, you are capable of great things. 

She’s also aware of her limits. “I think I was addicted to adversity,” she says. “It had to be hard because that’s how I knew how to operate. But I’m telling you, there’s a way better way, a more efficient way, a more fulfilling way to go about being in athletics.”

After more than a decade of wrestling and MMA competition culminating in her UFC World Championship in 2016, she says her life came tumbling down. Years of relentless training, a toxic relationship, and overwhelming burning-the-candle-at-both-ends stress wore her out. So, she stepped out of the octagon and took a step back to reassess how she’d been approaching her life.

“I retired from the sport and it took five years to figure out who I am other than Miesha Tate, the fighter,” she says. “So not only did I go soul searching, but I also went wellness searching.”

  • She found red light to help her recovery and healing, hyperbaric oxygen therapy to restore and protect her brain, and breathing techniques to keep her present and grounded.
  • She learned, too, the importance of mindfulness and attention to self—“to just be alone with your own thoughts.”
  • She says there’s reward and fulfillment in doing something every day that pushes you and makes you a little bit uncomfortable. No pain required.

She came back to professional MMA fighting after having two children and changed up nearly everything about her training. This included moving from Bantamweight to Flyweight, which meant reducing her already lean frame by another 10 pounds. It’s a change that better suits her natural build, redefines her fighting style, and allows her more power and reach.

She now looks at her body and mind as a comprehensive unit: the big things like hormones, nutrition, sleep and brain health; flow state during her fights; and she even takes on the more elusive soul work.

“When I walk into the octagon, I’m working on incorporating my soul more to be honest,” she says. “I don’t feel like it has been a very mindful part of my fighting. A lot of people say, “you’ve got that warrior spirit.” It probably is my spirit, it’s just not on a conscious level. I would like to bring it on a conscious level, and I’m a work in progress, just like everybody.”

Miesha focuses on empowering women through martial arts, with a particular emphasis on self-defense and building confidence. She’s become an advocate for women in combat sports, using her platform to promote equality and opportunities for women in the sport. She also helps others heal, recover, and discover their potential at Desert Moon Wellness, which she co-founded with two women partners.

In addition to her business and professional ventures, Miesha’s also involved in various philanthropic endeavors. She lists her three most important things in life as: 1) Family and friends, 2) time, and 3) goals and dreams.

Watch this episode on YouTube!

“My children really motivated me to be the best version of myself because if I'm not the best version of myself, there's no way they get the best version of me.”

Miesha Tate

Enjoy the show!

LISTEN: “Follow” or “subscribe” to The Human Upgrade™ with Dave Asprey on your favorite podcast platform.

REVIEW: Go to Apple Podcasts at daveasprey.com/apple and leave a (hopefully) 5-star rating and a creative review.

FEEDBACK: Got a comment, idea or question for the podcast? Submit via this form!

SOCIAL: Follow @thehumanupgradepodcast on Instagram and Facebook.

JOIN: Learn directly from Dave Asprey alongside others in a membership group: ourupgradecollective.com.

  • Our Partners
  • Links & Resources
  • Key Notes

Must-Have Magnesium: https://magbreakthrough.com/dave, use code DAVE10 to get a 10% discount

Micronutrients Boost HRV: https://modemethod.com, use code DAVE to get 15% off your first order

Get your tickets now to join the 9th Annual Biohacking Conference: https://biohackingconference.com

  • Coming soon!

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Daily Habits That Power Up & Change Your Brain – Daniel Amen, M.D. – #1032

EPISODE #1032

Daily Habits That Power Up & Change Your Brain

Daniel Amen, M.D.

Here’s exactly what to do every single day—for the next year—to keep your brain sharp and rock your life.

Daniel_Amen_white_chair

In this Episode of The Human Upgrade™...

Daniel Amen, M.D., shares the most effective daily habits you can do to improve the way your brain works, based on his 40 years of clinical practice.

In this discussion and in his new book, “Change Your Brain Every Day: Simple Daily Practices to Strengthen Your Mind, Memory, Moods, Focus, Energy, Habits, and Relationships,” he delivers a year’s worth of habits to you in short info bits and daily actions.

Incorporating Dr. Amen’s tiny habits and practices will help you:

  • Manage your mind to support your happiness, inner peace, and success
  • Develop lifelong strategies for dealing with whatever stresses come your way
  • Create an ongoing sense of purpose in a way that informs your daily actions
  • Learn major life lessons Dr. Amen has gleaned from studying hundreds of thousands of brain scans

As a psychiatrist and clinical neuroscientist, Dr. Amen has collected the world’s largest database of brain scans for psychiatry. This totals more than 210,000 SPECT scans on patients from 155 countries. This has been key to going beyond what he learned as a psychiatrist. Actually observing “the organ” in question has been a game changer for his mission to end mental illness by creating a revolution in brain health.

This is Dr. Amen’s sixth time on the podcast and he doesn’t disappoint. He teaches you how your gut affects your thinking, how mental health is really brain health, and how measuring brain function is tied to mitochondrial function.

A key innovator in the world of brain health, Dr. Amen completely shifts the paradigm of understanding what’s happening in your brain. His new book is a must-have for anyone who values both their brain function and mental health. 

Watch this episode on YouTube

“There is nowhere in school where school teaches you to manage your mind. Nowhere. And that's insane.”

Daniel Amen, M.D.

Enjoy the show!

LISTEN: “Follow” or “subscribe” to The Human Upgrade™ with Dave Asprey on your favorite podcast platform.

REVIEW: Go to Apple Podcasts at daveasprey.com/apple and leave a (hopefully) 5-star rating and a creative review.

FEEDBACK: Got a comment, idea or question for the podcast? Submit via this form!

SOCIAL: Follow @thehumanupgradepodcast on Instagram and Facebook.

JOIN: Learn directly from Dave Asprey alongside others in a membership group: ourupgradecollective.com.

  • Our Partners
  • Links & Resources
  • Key Notes

Sleep Solutions for High Performance: https://sleepbreakthrough.com/dave, use code DAVE10 to get an extra 10% off

Capture Life Force Energy: https://leelaq.com, use discount code DAVE10 to get 10% off sitewide

Comfort Options for Hot & Cold Sleepers: https://sleep.me/daveasprey, use code ASPREY for 25% off

  • Coming soon!

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How to Increase Neuroplasticity and Strengthen Your Brain – Moha Bensofia – #1031

EPISODE #1031

How to Increase Neuroplasticity and Strengthen Your Brain

Moha Bensofia / Mendi

Training your brain to be stronger creates new pathways that allow for more mental flexibility and higher function. 

Moha_Bensofia

In this Episode of The Human Upgrade™...

… you’ll learn how much control you can actually have over your brain. There’s a new way of accessing your meat operating system that adds an important element that’s been missing from the brain training conversation. Moha Bensofia joins the show to explain a new piece of neurotech called Mendi. He shares the benefits of getting more blood to the front of your brain.

Initially, Moha was an investor in Mendi, but as he recognized the power of this real-time medical-grade neurofeedback device to train people’s brains, he stepped in as CEO.

Mendi uses neurofeedback to provide visual feedback based on your brain activity. A headset measures the activity while you play a fun brain-training mobile game. The system uses fNIRS technology to measure blood flow and oxygenation in the pre-frontal cortex of the brain. The brain training game requires focus and calmness, which increases activity and control of your brain’s pathways. 

“Our brains are constantly overstimulated, which makes them difficult to control,” Moha says. He believes that by using Mendi you can learn to control your brain activity and reach greater heights as an entrepreneur, athlete, and professional in any field.

Mendi was developed initially for victims of war and trauma, as well as people struggling with anxiety, PTSD, and ADHD. But, as you’ll learn, everyone can benefit from this type of brain training.

SPECIAL OFFER FOR THE HUMAN UPGRADE LISTENERS:  Go to https://www.mendi.io and use code DAVE to save 15%.

Watch this episode on YouTube!

“I like to look at [Mendi brain training] as kind of the Tinder model where you swipe things left or right. Imagine if you could just basically teach yourself to not swipe into that dark place."

Moha Bensofia / Mendi

Enjoy the show!

LISTEN: “Follow” or “subscribe” to The Human Upgrade™ with Dave Asprey on your favorite podcast platform.

REVIEW: Go to Apple Podcasts at daveasprey.com/apple and leave a (hopefully) 5-star rating and a creative review.

FEEDBACK: Got a comment, idea or question for the podcast? Submit via this form!

SOCIAL: Follow @thehumanupgradepodcast on Instagram and Facebook.

JOIN: Learn directly from Dave Asprey alongside others in a membership group: ourupgradecollective.com.

  • Our Partners
  • Links & Resources
  • Key Notes

Liquid Ketones for Better Energy, Focus & Endurance: https://hvmn.com, use code DAVE to get 20% off

Join us at the 9th Annual Biohacking Conference: https://biohackingconference.com

Dave Asprey’s NEW Book! “Smarter Not Harder: The Biohacker’s Guide to Getting the Body and Mind You Want” is out now. https://daveasprey.com/books/

  • Coming Soon!

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How to Get & Stay Sober—Even if You Don’t Think You’re an Addict – Luke Storey – #1030

EPISODE #1030

How to Get & Stay Sober—Even if You Don’t Think You’re an Addict

Luke Storey

Learn about the different types of addiction (not just substance!), the healing benefits of psychedelics and social connection in recovery, and how to get your life back.

Luke Storey

In this Episode of The Human Upgrade™...

… you’ll learn Luke Storey’s definition of addiction and his strategies for healing, happiness, and high performance. He’s known for his irreverent, passionate, and humorous delivery, and it shows through in this conversation.

He overcame tremendous adversity from childhood trauma, adolescent criminality, and years of chronic alcohol and drug addiction. For 25 years, he’s focused on recovery, inner work, and personal development. If you’re currently working on addiction recovery, you’ll learn a lot from his experience. And even if you don’t share any aspect of Luke’s dark background, you may have your own type of addiction that could benefit from his wisdom.

“Even if we don’t have an addiction to a substance or a behavior,” Luke explains, “many of us are addicted to false thoughts that we continually think that we can’t stop.”

Luke’s a great writer, meditation and metaphysics teacher and lifestyle design expert who shares with you his transformative principles of health, addiction recovery, and spirituality. This discussion dives deep into addiction, how psychedelics—properly used with the help of a professional—can aid your recovery, and what it really takes to live and thrive once you get sober.

He’s spent the past two decades refining and defining the ultimate wellness lifestyle. His teachings combine primal health and ancient spiritual practices with natural healing and consciousness-expanding technologies. His own Life Stylist Podcast covers a range of topics including sex and relationships, yoga, meditation, health myths and medical conspiracies, spirituality, mindfulness, and a whole lot more.

SPECIAL ANNOUNCEMENT FOR THE HUMAN UPGRADE LISTENERS: Protect yourself, your home, and your family from the dangers of EMF and 5G with Luke Storey’s EMF Home Safety Masterclass. Find the class at online.lukestorey.com

Watch this episode on YouTube!

“One of the main underlying issues in addiction is loneliness and a disconnect from other people.”

Luke Storey

Enjoy the show!

LISTEN: “Follow” or “subscribe” to The Human Upgrade™ with Dave Asprey on your favorite podcast platform.

REVIEW: Go to Apple Podcasts at daveasprey.com/apple and leave a (hopefully) 5-star rating and a creative review.

FEEDBACK: Got a comment, idea or question for the podcast? Submit via this form!

SOCIAL: Follow @thehumanupgradepodcast on Instagram and Facebook.

JOIN: Learn directly from Dave Asprey alongside others in a membership group: ourupgradecollective.com.

  • Our Partners
  • Links & Resources
  • Key Notes

Must-Have Magnesium: https://magbreakthrough.com/dave, use code DAVE10 to get a 10% discount

A Probiotic to Ease Stress: https://www.omnibioticlife.com/DAVE, use code DAVE20 to get 20% off

Dave Asprey’s NEW Book! “Smarter Not Harder: The Biohacker’s Guide to Getting the Body and Mind You Want” is out now. https://daveasprey.com/books/

Coming soon!

Listen and Subscribe using your favorite podcast provider

How to Challenge Outdated Beliefs About Aging – Steven Kotler – #1026

EPISODE #1026

How to Challenge Outdated Beliefs About Aging

Steven Kotler

Learn new ways to use your brain, test your limits and challenge yourself as you age.

Steven_Kotler_credit_ryan_heffernan

In this Episode of The Human Upgrade™...

IN THIS EPISODE OF THE HUMAN UPGRADE™… you will learn about the beliefs that kick in as normal humans age and most importantly, you will learn what you can do about those limiting beliefs. And who better to discuss this than the author of the book, “Gnar Country: Growing Old, Staying Rad,” Steven Kotler. 

Steven is a friend of the show, executive director of the Flow Research Collective, a New York Times bestselling author, and an award-winning journalist. He tested his knowledge and theories on himself in a quest to learn how to park ski (an extreme type of skiing) at age 53.

Science shows that older humans are better at learning certain skills than younger people. Brain changes occur in the second half of your life that unlock levels of intelligence, wisdom, creativity, and empathy you didn’t know were possible.

In the conversation, Steven describes how his book chronicles his experience pushing his own aging body past preconceived limits. He also explains why he wrote a book about goals, grit and progression – and why he feels it’s an important lesson for everyone to learn (not just those of you over 50). 

Steven also explains why he chose extreme skiing as his No. 1 anti-aging activity. “… if you really want to preserve cognitive function, you want to basically use the hippocampus in the way that evolution designed it. You want novel, challenging experiences in outdoor environments.”

Steven’s been on the show several times before, most recently episode #784 talking about motivators that fuel peak performance. This time, Steven helps us challenge the outdated beliefs about aging that started long ago and never got fixed.

Watch this episode on Youtube.

"If fine motor coordination and manual dexterity decline over time, there's no way a 92-year-old dude (Stradivarius) makes a priceless viola."

Steven Kotler

Research Mentioned in this EpisodeBlue Zone research.

More About Steven’s book: “Gnar Country” is an antidote for weariness that is inspiring, practical, and, often hilarious. It is about growing old and staying rad. It’s a feverish reading experience that makes you put down the book, get out there, and move. Whether hurtling down a mountain side, running your first 10K race, or taking your career to new heights, Steven challenges you to test yourself, surpass your limits, and achieve your own impossible, whatever it might be. Part personal journey, part science experiment, part how-to guide, Kotler takes us on his punk rock, high-velocity joy-ride for a better life in spite—and often in defiance of—the perceived limitations of the aging human body.

Enjoy the show!

LISTEN: “Follow” or “subscribe” to The Human Upgrade™ with Dave Asprey on your favorite podcast platform.

REVIEW: Go to Apple Podcasts at daveasprey.com/apple and leave a (hopefully) 5-star rating and a creative review.

FEEDBACK: Got a comment, idea or question for the podcast? Submit via this form!

SOCIAL: Follow @thehumanupgradepodcast on Instagram and Facebook.

JOIN: Learn directly from Dave Asprey alongside others in a membership group: ourupgradecollective.com.

  • Our Partners
  • Links & Resources
  • Key Notes

Dave Asprey’s NEW Book! “Smarter Not Harder: The Biohacker’s Guide to Getting the Body and Mind You Want” launches Feb. 28, 2023.  IndieBound / Barnes & Noble / Apple Books / Amazon

Join us at the 9th Annual Biohacking Conference: https://biohackingconference.com

  • Coming soon!

Listen and Subscribe using your favorite podcast provider

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