Ochratoxin Medical Literature
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Hope Janette H., Hope Bradley E.. A review of the diagnosis and treatment of Ochratoxin A inhalational exposure associated with human illness and kidney disease including focal segmental glomerulosclerosis. Journal of environmental and public health. 2012;2012.
Khoury André, Atoui Ali. Ochratoxin a: general overview and actual molecular status. Toxins. 2010;2:461–493.
Kuiper-Goodman T., Scott P. M.. Risk assessment of the mycotoxin ochratoxin A. Biomedical and environmental sciences : BES. 1989;2:179–248.
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Prabu P. C., Dwivedi P., Sharma A. K.. Toxicopathological studies on the effects of aflatoxin B(1), ochratoxin A and their interaction in New Zealand White rabbits. Experimental and toxicologic pathology. 2013;65:277–286.
Shen Xiao Li L., Zhang Yu, Xu Wentao, et al. An iTRAQ-based mitoproteomics approach for profiling the nephrotoxicity mechanisms of ochratoxin A in HEK 293 cells. Journal of proteomics. 2013;78:398–415.
Stachurska Anna, Ciesla Maciej, Kozakowska Magdalena, et al. Cross-talk between microRNAs, nuclear factor E2-related factor 2, and heme oxygenase-1 in ochratoxin A induced toxic effects in renal proximal tubular epithelial cells. Molecular nutrition & food research. 2013;57:504–515.
Pleadin Jelka, Perši Nina, Mitak Mario, et al. Biochemical changes in pig serum after ochratoxin A exposure. Bulletin of environmental contamination and toxicology. 2012;88:1043–1047.
Hmaissia Khlifa K., Ghali R., Mazigh C., Aouni Z., Machgoul S., Hedhili A.. Ochratoxin A levels in human serum and foods from nephropathy patients in Tunisia: where are you now? Experimental and toxicologic pathology. 2012;64:509–512.
Kumar Manoj, Dwivedi Prabhaker, Sharma Anil Kumar K., Sankar Muthu, Patil Rajendra D., Singh Nittin Dev D.. Apoptosis and lipid peroxidation in ochratoxin A- and citrinin-induced nephrotoxicity in rabbits. Toxicology and industrial health. 2012.
Jilani Kashif, Lupescu Adrian, Zbidah Mohanad, Abed Majed, Shaik Nazneen, Lang Florian. Enhanced apoptotic death of erythrocytes induced by the mycotoxin ochratoxin A. Kidney & blood pressure research. 2012;36:107–118.
Sorrenti Valeria, Di Giacomo Claudia, Acquaviva Rosaria, et al. Dimethylarginine dimethylaminohydrolase/nitric oxide synthase pathway in liver and kidney: protective effect of cyanidin 3-O-?-D-glucoside on ochratoxin-A toxicity. Toxins. 2012;4:353–363.
Li Zengning, Zhang Xianghong, Cui Jinfeng, Kang Weijun. Assessment on pollution of Ochratoxin A in grain in China and its apoptosis effect on vitro-cultured human tubular kidney cells. Journal of biochemical and molecular toxicology. 2012;26:139–146.
Hennemeier Isabell, Humpf Hans-Ulrich U., Gekle Michael, Schwerdt Gerald. The food contaminant and nephrotoxin ochratoxin A enhances Wnt1 inducible signaling protein 1 and tumor necrosis factor-? expression in human primary proximal tubule cells. Molecular nutrition & food research. 2012;56:1375–1384.
Stoev Stoycho D., Gundasheva Dimitrina, Zarkov Ivan, et al. Experimental mycotoxic nephropathy in pigs provoked by a mouldy diet containing ochratoxin A and fumonisin B1. Experimental and toxicologic pathology. 2012;64:733–741.
Klari? Maja Segvi? S., Zelježi? Davor, Rumora Lada, Peraica Maja, Pepeljnjak Stjepan, Domijan Ana-Marija M.. A potential role of calcium in apoptosis and aberrant chromatin forms in porcine kidney PK15 cells induced by individual and combined ochratoxin A and citrinin. Archives of toxicology. 2012;86:97–107.
Jennings Paul, Weiland Christina, Limonciel Alice, et al. Transcriptomic alterations induced by Ochratoxin A in rat and human renal proximal tubular in vitro models and comparison to a rat in vivo model. Archives of toxicology. 2012;86:571–589.
Taniai Eriko, Hayashi Hitomi, Yafune Atsunori, et al. Cellular distribution of cell cyclerelated molecules in the renal tubules of rats treated with renal carcinogens for 28 days: relationship between cell cycle aberration and carcinogenesis. Archives of toxicology. 2012;86:1453–1464.
Mally Angela. Ochratoxin a and mitotic disruption: mode of action analysis of renal tumor formation by ochratoxin A. Toxicological sciences : an official journal of the Society of Toxicology. 2012;127:315–330.
Radford Robert, Slattery Craig, Jennings Paul, et al. Carcinogens induce loss of the primary cilium in human renal proximal tubular epithelial cells independently of effects on the cell cycle. American journal of physiology. Renal physiology. 2012;302. Jutabha Promsuk, Anzai Naohiko, Hayashi Keitaro, et al. A novel human organic anion transporter NPT4 mediates the transport of ochratoxin A. Journal of pharmacological sciences. 2011;116:392–396.
Zaied Chiraz, Bouaziz Chayma, Azizi Islam, et al. Presence of ochratoxin A in Tunisian blood nephropathy patients. Exposure level to OTA. Experimental and toxicologic pathology. 2011;63:613–618.
Duarte Sofia Cancela C., Pena Angelina, Lino Celeste Matos M.. Human ochratoxin a biomarkers–from exposure to effect. Critical reviews in toxicology. 2011;41:187–212. Stachurska Anna, Kozakowska Magdalena, Jozkowicz Alicja, Dulak Jozef, Loboda Agnieszka. Aristolochic acid I and ochratoxin A differentially regulate VEGF expression in porcine kidney epithelial cells–the involvement of SP-1 and HIFs transcription factors. Toxicology letters. 2011;204:118–126.
Desalegn Biruck, Nanayakkara Shanika, Harada Kouji H., et al. Mycotoxin detection in urine samples from patients with chronic kidney disease of uncertain etiology in Sri Lanka. Bulletin of environmental contamination and toxicology. 2011;87:6–10.
Vettorazzi Ariane, Trocóniz Iñaki Fernández F., González-Peñas Elena, et al. Kidney and liver distribution of ochratoxin A in male and female F344 rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2011;49:1935–1942.
Mili?evi? Dragan, Jovanovi? Milijan, Matekalo-Sverak Vesna, Radicevi? Tatjana, Petrovi? Milan M., Lili? Slobodan. A survey of spontaneous occurrence of ochratoxin A residues in chicken tissues and concurrence with histopathological changes in liver and kidneys. Journal of environmental science and health. Part C, Environmental carcinogenesis & ecotoxicology reviews. 2011;29:159–175.
Hibi Daisuke, Suzuki Yuta, Ishii Yuji, et al. Site-specific in vivo mutagenicity in the kidney of gpt delta rats given a carcinogenic dose of ochratoxin A. Toxicological sciences : an official journal of the Society of Toxicology. 2011;122:406–414.
Li Jinghua, Yin Shutao, Dong Yinhui, Fan Lihong, Hu Hongbo. p53 activation inhibits ochratoxin A-induced apoptosis in monkey and human kidney epithelial cells via suppression of JNK activation. Biochemical and biophysical research communications. 2011;411:458–463.
Abdu Suzan, Ali Awatif, Ansari Shatha. Cytotoxic effect of ochratoxin A on the renal corpuscles of rat kidney: could ochratoxin A cause kidney failure? Histology and histopathology. 2011;26:543–549.
Ellis James Keith K., Athersuch Toby James J., Cavill Rachel, et al. Metabolic response to low-level toxicant exposure in a novel renal tubule epithelial cell system. Molecular bioSystems. 2011;7:247–257.
Mantle Peter G., Dobrota Miloslav, Gillett Cheryl E., Odell Edward W., Pinder Sarah E.. Oncological outcomes in rats given nephrocarcinogenic exposure to dietary ochratoxin a, followed by the tumour promoter sodium barbital for life: a pilot study. Toxins. 2010;2:552–571.
Golli-Bennour Emna El E., Kouidhi Bochra, Bouslimi Amel, Abid-Essefi Salwa, Hassen Wafa, Bacha Hassen. Cytotoxicity and genotoxicity induced by aflatoxin B1, ochratoxin A, and their combination in cultured Vero cells. Journal of biochemical and molecular toxicology. 2010;24:42–50.
Hoffmann Dana, Fuchs Tobias C., Henzler Tanja, et al. Evaluation of a urinary kidney biomarker panel in rat models of acute and subchronic nephrotoxicity. Toxicology. 2010;277:49–58.
Mantle Peter G., Amerasinghe Cyrille, Brown Amy L., et al. A pilot study of nuclear instability in archived renal and upper urinary tract tumours with putative ochratoxin aetiology. Toxins. 2010;2:326–340.
Stoev S. D., Dutton M. F., Njobeh P. B., Mosonik J. S., Steenkamp P. A.. Mycotoxic nephropathy in Bulgarian pigs and chickens: complex aetiology and similarity to Balkan endemic nephropathy. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment. 2010;27:72–88.
Mantle Peter G., McHugh Katharine M., Fincham John E.. Contrasting nephropathic responses to oral administration of extract of cultured Penicillium polonicum in rat and primate. Toxins. 2010;2:2083–2097.
Anzai Naohiko, Jutabha Promsuk, Endou Hitoshi. Molecular mechanism of ochratoxin a transport in the kidney. Toxins. 2010;2:1381–1398.
Mantle Peter G., Nolan Christopher C.. Pathological outcomes in kidney and brain in male Fischer rats given dietary ochratoxin A, commencing at one year of age. Toxins. 2010;2:1100–1110.
Mantle Peter, Kulinskaya Elena. Lifetime, low-dose ochratoxin A dietary study on renal carcinogenesis in male Fischer rats. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment. 2010;27:1566–1573.
Aoudia N., Callu P., Grosjean F., Larondelle Y.. Effectiveness of mycotoxin sequestration activity of micronized wheat fibres on distribution of ochratoxin A in plasma, liver and kidney of piglets fed a naturally contaminated diet. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2009;47:1485–1489.
Schwerdt Gerald, Holzinger Hildegard, Königs Maika, Humpf Hans-Ulrich U., Gekle Michael. Effect of ochratoxin A on cell survival and collagen homeostasis in human mesangial cells in primary culture. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2009;47:209–213.
Domijan Ana-Marija M., Peraica Maja, Markov Ksenija, Fuchs Radovan. Urine ochratoxin a and sphinganine/sphingosine ratio in residents of the endemic nephropathy area in Croatia. Arhiv za higijenu rada i toksikologiju. 2009;60:387–393.
Pfohl-Leszkowicz Annie. Ochratoxin A and aristolochic acid involvement in nephropathies and associated urothelial tract tumours. Arhiv za higijenu rada i toksikologiju. 2009;60:465–483.
Boesch-Saadatmandi C., Wagner A. E., Graeser A. C., Hundhausen C., Wolffram S., Rimbach G.. Ochratoxin A impairs Nrf2-dependent gene expression in porcine kidney tubulus cells. Journal of animal physiology and animal nutrition. 2009;93:547–554.
Zlender Vilim, Breljak Davorka, Ljubojevi? Marija, et al. Low doses of ochratoxin A upregulate the protein expression of organic anion transporters Oat1, Oat2, Oat3 and Oat5 in rat kidney cortex. Toxicology and applied pharmacology. 2009;239:284–296.
Mantle Peter G.. Minimum tolerable exposure period and maximum threshold dietary intake of ochratoxin A for causing renal cancer in male Dark Agouti rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2009;47:2419–2424.
Stemmer Kerstin, Ellinger-Ziegelbauer Heidrun, Ahr Hans-Jürgen J., Dietrich Daniel R.. Molecular characterization of preneoplastic lesions provides insight on the development of renal tumors. The American journal of pathology. 2009;175:1686–1698.
Bouslimi Amel, Bouaziz Chayma, Ayed-Boussema Imen, Hassen Wafa, Bacha Hassen. Individual and combined effects of ochratoxin A and citrinin on viability and DNA fragmentation in cultured Vero cells and on chromosome aberrations in mice bone marrow cells. Toxicology. 2008;251:1–7.
Peraica Maja, Domijan Ana-Marija M., Sari? Marko. Mycotoxic and aristolochic acid theories of the development of endemic nephropathy. Arhiv za higijenu rada i toksikologiju. 2008;59:59–65.
Yokoyama Hirokazu, Anzai Naohiko, Ljubojevic Marija, et al. Functional and immunochemical characterization of a novel organic anion transporter Oat8 (Slc22a9) in rat renal collecting duct. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2008;21:269–278.
Mili?evi? Dragan, Juri? Verica, Stefanovi? Srdan, Jovanovi? Milijan, Jankovi? Sasa. Survey of slaughtered pigs for occurrence of ochratoxin A and porcine nephropathy in Serbia. International journal of molecular sciences. 2008;9:2169–2183.
Mantle Peter G., Nagy Judit M.. Binding of ochratoxin A to a urinary globulin: a new concept to account for gender difference in rat nephrocarcinogenic responses. International journal of molecular sciences. 2008;9:719–735.
Bouslimi Amel, Ouannes Zouhour, Golli Emna El E., Bouaziz Chayma, Hassen Wafa, Bacha Hassen. Cytotoxicity and oxidative damage in kidney cells exposed to the mycotoxins ochratoxin a and citrinin: individual and combined effects. Toxicology mechanisms and methods. 2008;18:341–349.
Peraica Maja, Domijan Ana-Marija M., Mileti?-Medved Marica, Fuchs Radovan. The involvement of mycotoxins in the development of endemic nephropathy. Wiener klinische Wochenschrift. 2008;120:402–407.
Hmaissia Khlifa K., Ghali R., Mezigh C., et al. Serum levels of ochratoxin A in healthy subjects and in nephropathic patients in Tunisia. Annales de biologie clinique. 2008;66:631–636.
Rached Eva, Hoffmann Dana, Blumbach Kai, Weber Klaus, Dekant Wolfgang, Mally Angela. Evaluation of putative biomarkers of nephrotoxicity after exposure to ochratoxin a in vivo and in vitro. Toxicological sciences : an official journal of the Society of Toxicology. 2008;103:371–381.
Arbillaga Leire, Vettorazzi Ariane, Gil Ana G., Delft Joost Hm H., García-Jalón José Antonio A., Cerain Adela. Gene expression changes induced by ochratoxin A in renal and hepatic tissues of male F344 rat after oral repeated administration. Toxicology and applied pharmacology. 2008;230:197–207.
Boesch-Saadatmandi C., Loboda A., Jozkowicz A., et al. Effect of ochratoxin A on redox-regulated transcription factors, antioxidant enzymes and glutathione-Stransferase in cultured kidney tubulus cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2008;46:2665–2671.
Wanigasuriya Kamani P., Peiris Hemantha, Ileperuma Nalaka, Peiris-John Roshini J., Wickremasinghe Rajitha. Could ochratoxin A in food commodities be the cause of chronic kidney disease in Sri Lanka? Transactions of the Royal Society of Tropical Medicine and Hygiene. 2008;102:726–728.
Karmaus Wilfried, Dimitrov Plamen, Simeonov Valeri, Tsolova Svetla, Bonev Angel, Georgieva Rossitza. Metals and kidney markers in adult offspring of endemic nephropathy patients and controls: a two-year follow-up study. Environmental health : a global access science source. 2008;7.
Verma Ramtej, Chakraborty Devjani. Alterations in DNA, RNA and protein contents in liver and kidney of mice treated with ochratoxin and their amelioration by Emblica officinalis aqueous extract. Acta poloniae pharmaceutica. 2008;65:3–9.
Delatour Thierry, Mally Angela, Richoz Janique, et al. Absence of 2?-deoxyguanosinecarbon 8-bound ochratoxin A adduct in rat kidney DNA monitored by isotope dilution LCMS/MS. Molecular nutrition & food research. 2008;52:472–482.
Schmidt-Heydt M., Geisen R.. Gene expression as an indication for ochratoxin A biosynthesis in Penicillium nordicum. Mycotoxin research. 2007;23:13–21.
Rached Eva, Hard Gordon C., Blumbach Kai, et al. Ochratoxin A: 13-week oral toxicity and cell proliferation in male F344/n rats. Toxicological sciences : an official journal of the Society of Toxicology. 2007;97:288–298.
Mally A., Hard G. C., Dekant W.. Ochratoxin A as a potential etiologic factor in endemic nephropathy: lessons from toxicity studies in rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2007;45:2254–2260.
Stemmer Kerstin, Ellinger-Ziegelbauer Heidrun, Ahr Hans-Juergen J., Dietrich Daniel R.. Carcinogen-specific gene expression profiles in short-term treated Eker and wild-type rats indicative of pathways involved in renal tumorigenesis. Cancer research. 2007;67:4052–4068.
Brown Amy L., Odell Edward W., Mantle Peter G.. DNA ploidy distribution in renal tumours induced in male rats by dietary ochratoxin A. Experimental and toxicologic pathology. 2007;59:85–95.
Schwerdt Gerald, Holzinger Hildegard, Sauvant Christoph, Königs Maika, Humpf Hans-Ulrich U., Gekle Michael. Long-term effects of ochratoxin A on fibrosis and cell death in human proximal tubule or fibroblast cells in primary culture. Toxicology. 2007;232:57–67.
Pfohl-Leszkowicz Annie, Tozlovanu Mariana, Manderville Richard, Peraica Maja, Castegnaro Marcel, Stefanovic Vladislav. New molecular and field evidences for the implication of mycotoxins but not aristolochic acid in human nephropathy and urinary tract tumor. Molecular nutrition & food research. 2007;51:1131–1146.
Kumar Manoj, Dwivedi Prabhaker, Sharma Anil K., Singh Nittin Dev D., Patil Rajendra D.. Ochratoxin A and citrinin nephrotoxicity in New Zealand White rabbits: an ultrastructural assessment. Mycopathologia. 2007;163:21–30.
Dinis A. M., Lino C. M., Pena A. S.. Ochratoxin A in nephropathic patients from two cities of central zone in Portugal. Journal of pharmaceutical and biomedical analysis. 2007;44:553–557.
Grajewski J., Jarzemski P., Twaruzek M., Kuzminska K., Trepala M.. The level of ochratoxin a in patients after nephrectomy. Mycotoxin research. 2007;23:22–26.
Arbillaga Leire, Azqueta Amaia, Ezpeleta Olga, Cerain Adela. Oxidative DNA damage induced by Ochratoxin A in the HK-2 human kidney cell line: evidence of the relationship with cytotoxicity. Mutagenesis. 2007;22:35–42.
Marin-Kuan M., Nestler S., Verguet C., et al. MAPK-ERK activation in kidney of male rats chronically fed ochratoxin A at a dose causing a significant incidence of renal carcinoma. Toxicology and applied pharmacology. 2007;224:174–181.
Costa S., Utan A., Cervellati R., Speroni E., Guerra M. C.. Catechins: natural freeradical scavengers against ochratoxin A-induced cell damage in a pig kidney cell line (LLC-PK1). Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2007;45:1910–1917.
Klari? Maja Segvi? S., Pepeljnjak Stjepan, Domijan Ana-Marija M., Petrik József. Lipid peroxidation and glutathione levels in porcine kidney PK15 cells after individual and combined treatment with fumonisin B(1), beauvericin and ochratoxin A. Basic & clinical pharmacology & toxicology. 2007;100:157–164.
Heussner A. H., O?Brien E., Dietrich D. R.. Effects of repeated ochratoxin exposure on renal cells in vitro. Toxicology in vitro : an international journal published in association with BIBRA. 2007;21:72–80.
Rached Eva, Pfeiffer Erika, Dekant Wolfgang, Mally Angela. Ochratoxin A: apoptosis and aberrant exit from mitosis due to perturbation of microtubule dynamics? Toxicological sciences : an official journal of the Society of Toxicology. 2006;92:78–86.
Gresham A., Done S., Livesey C., et al. Survey of pigs? kidneys with lesions consistent with PMWS and PDNS and ochratoxicosis. Part 2: pathological and histological findings. The Veterinary record. 2006;159:761–768.
Domijan Ana-Marija M., Zeljezi? Davor, Kopjar Nevenka, Peraica Maja. Standard and Fpg-modified comet assay in kidney cells of ochratoxin A- and fumonisin B(1)-treated rats. Toxicology. 2006;222:53–59.
Faucet-Marquis Virginie, Pont Frédéric, Størmer Frederik C., Rizk Toufik, Castegnaro Marcel, Pfohl-Leszkowicz Annie. Evidence of a new dechlorinated ochratoxin A derivative formed in opossum kidney cell cultures after pretreatment by modulators of glutathione pathways: correlation with DNA-adduct formation. Molecular nutrition & food research. 2006;50:530–542.
Gresham A., Done S., Livesey C., et al. Survey of pigs? kidneys with lesions consistent with PMWS and PDNS and ochratoxicosis. Part 1: concentrations and prevalence of ochratoxin A. The Veterinary record. 2006;159:737–742.
Zeljezi? D., Domijan A-M M., Peraica M.. DNA damage by ochratoxin A in rat kidney assessed by the alkaline comet assay. Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica … [et al.]. 2006;39:1563–1568.
Mally Angela, Decker Martina, Bekteshi Michaela, Dekant Wolfgang. Ochratoxin A alters cell adhesion and gap junction intercellular communication in MDCK cells. Toxicology. 2006;223:15–25.
Bow Daniel A., Perry Jennifer L., Simon John D., Pritchard John B.. The impact of plasma protein binding on the renal transport of organic anions. The Journal of pharmacology and experimental therapeutics. 2006;316:349–355.
Heussner A. H., Dietrich D. R., O?Brien E.. In vitro investigation of individual and combined cytotoxic effects of ochratoxin A and other selected mycotoxins on renal cells. Toxicology in vitro : an international journal published in association with BIBRA. 2006;20:332–341.
Mally Angela, Keim-Heusler Heike, Amberg Alexander, et al. Biotransformation and nephrotoxicity of ochratoxin B in rats. Toxicology and applied pharmacology. 2005;206:43–53.
Fuchs R., Peraica M.. Ochratoxin A in human kidney diseases. Food additives and contaminants. 2005;22 Suppl 1:53–57.
Domijan Ana-Marija M., Rudes Kamilo, Peraica Maja. The effect of ochratoxin A on the concentration of protein carbonyls in rats. Arhiv za higijenu rada i toksikologiju. 2005;56:311–315.
Mally Angela, Völkel Wolfgang, Amberg Alexander, et al. Functional, biochemical, and pathological effects of repeated oral administration of ochratoxin A to rats. Chemical research in toxicology. 2005;18:1242–1252.
Knecht A., Schwerdt G., Gekle M., Humpf H-U U.. Combinatory effects of citrinin and ochratoxin A in immortalized human proximal tubule cells. Mycotoxin research. 2005;21:176–181.
Kamp Hennicke G., Eisenbrand Gerhard, Janzowski Christine, et al. Ochratoxin A induces oxidative DNA damage in liver and kidney after oral dosing to rats. Molecular nutrition & food research. 2005;49:1160–1167.
Sauvant C., Holzinger H., Gekle M.. Proximal tubular toxicity of ochratoxin A is amplified by simultaneous inhibition of the extracellular signal-regulated kinases 1/2. The Journal of pharmacology and experimental therapeutics. 2005;313:234–241.
Gagliano Nicoletta, Torri Carlo, Donetti Elena, et al. Ochratoxin A-induced renal cortex fibrosis and epithelial-to-mesenchymal transition: molecular mechanisms of ochratoxin A-injury and potential effects of red wine. Molecular medicine (Cambridge, Mass.). 2005;11:30–38.
Mantle Peter, Kulinskaya Elena, Nestler Sandra. Renal tumourigenesis in male rats in response to chronic dietary ochratoxin A. Food additives and contaminants. 2005;22 Suppl 1:58–64.
Kwak Jin-Oh O., Kim Hyun-Woo W., Oh Kwang-Jin J., Ko Chang-Bo B., Park Hwayong, Cha Seok Ho H.. Characterization of mouse organic anion transporter 5 as a renal steroid sulfate transporter. The Journal of steroid biochemistry and molecular biology. 2005;97:369–375.
Anzai Naohiko, Jutabha Promsuk, Enomoto Atsushi, et al. Functional characterization of rat organic anion transporter 5 (Slc22a19) at the apical membrane of renal proximal tubules. The Journal of pharmacology and experimental therapeutics. 2005;315:534–544.
Sauvant Christoph, Holzinger Hildegard, Gekle Michael. The nephrotoxin ochratoxin A induces key parameters of chronic interstitial nephropathy in renal proximal tubular cells. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2005;15:125–134.
Blazer-Yost Bonnie L., West T. Aaron, Stack Jamie, Peck Kerrie, Lahr Thomas F., Gekle Michael. Effect of the mycotoxin, ochratoxin A, on hormone-stimulated ion transport in a physiology. 2005;450:53–60.
Sauvant Christoph, Holzinger Hildegard, Mildenberger Sigrid, Gekle Michael. Exposure to nephrotoxic ochratoxin A enhances collagen secretion in human renal proximal tubular cells. Molecular nutrition & food research. 2005;49:31–37.
Domijan Ana-Marija M., Peraica Maja, Ferenci? Zeljko, et al. Ochratoxin A-induced apoptosis in rat kidney tissue. Arhiv za higijenu rada i toksikologiju. 2004;55:243–248.
Hassen Wafa, Abid Salwa, Achour Abdellatif, Creppy Edmond, Bacha Hassen. Ochratoxin A and beta2-microglobulinuria in healthy individuals and in chronic interstitial nephropathy patients in the centre of Tunisia: a hot spot of Ochratoxin A exposure. Toxicology. 2004;199:185–193.
Robbiano Luigi, Baroni Debora, Carrozzino Roberto, Mereto Eugenio, Brambilla Giovanni. DNA damage and micronuclei induced in rat and human kidney cells by six chemicals carcinogenic to the rat kidney. Toxicology. 2004;204:187–195.
Hassen Wafa, Abid-Essafi Salwa, Achour Abdellatif, et al. Karyomegaly of tubular kidney cells in human chronic interstitial nephropathy in Tunisia: respective role of Ochratoxin A and possible genetic predisposition. Human & experimental toxicology. 2004;23:339–346.
Hsieh Ming-Fang F., Chiu Hsiao-Ying Y., Lin-Tan Dan-Tzu T., Lin Ja-Liang L.. Does human ochratoxin A aggravate proteinuria in patients with chronic renal disease? Renal failure. 2004;26:311–316.
Blank Ralf, Wolffram Siegfried. Alkalinization of urinary pH accelerates renal excretion of ochratoxin A in pigs. The Journal of nutrition. 2004;134:2355–2358.
Zhang Xiaohong, Groves Carlotta E., Bahn Andrew, et al. Relative contribution of OAT and OCT transporters to organic electrolyte transport in rabbit proximal tubule. American journal of physiology. Renal physiology. 2004;287.
Lock Edward A., Hard Gordon C.. Chemically induced renal tubule tumors in the laboratory rat and mouse: review of the NCI/NTP database and categorization of renal carcinogens based on mechanistic information. Critical reviews in toxicology. 2004;34:211–299.
Youngblood Geri L., Sweet Douglas H.. Identification and functional assessment of the novel murine organic anion transporter Oat5 (Slc22a19) expressed in kidney. American journal of physiology. Renal physiology. 2004;287.
Gennari Alessandra, Pazos Patricia, Boveri Monica, et al. New insights into the mechanisms involved in renal proximal tubular damage induced in vitro by ochratoxin A. Journal of biochemical and molecular toxicology. 2004;18:43–49.
Schwerdt Gerald, Freudinger Ruth, Schuster Claudia, Silbernagl Stefan, Gekle Michael. Inhibition of mitochondria and extracellular acidification enhance achratoxin A-induced apoptosis in renal collecting duct-derived MDCK-C7 cells. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2004;14:47–56.
Aukema H. M., House J. D., Bankovic-Calic N., Ogborn M. R.. Increased renal fibrosis and expression of renal phosphatidylinositol 4-kinase-beta and phospholipase C (gamma1) proteins in piglets exposed to ochratoxin-A. Nephron. Physiology. 2004;96.
Froquet R., Le Dréan G., Parent-Massin D.. Effect of Ochratoxin A on human haematopoietic progenitors proliferation and differentiation: an in vitro study. Human & experimental toxicology. 2003;22:393–400.
Miljkovic Ana, Pfohl-Leszkowicz Annie, Dobrota Miloslav, Mantle Peter G.. Comparative extract of Penicillium polonicum in rats. Experimental and toxicologic pathology. 2003;54:305–312.
Weber F., Schwerdt G., Freudinger R., Gekle M.. Programmed cell death by interaction of ochratoxin A with other nephrotoxins. Mycotoxin research. 2003;19:20–23.
Abid Salwa, Hassen Wafa, Achour Abdellatif, et al. Ochratoxin A and human chronic nephropathy in Tunisia: is the situation endemic? Human & experimental toxicology. 2003;22:77–84.
Schwerdt Gerald, Freudinger Ruth, Schuster Claudia, Silbernagl Stefan, Gekle Michael. Inhibition of mitochondria prevents cell death in kidney epithelial cells by intra- and extracellular acidification. Kidney international. 2003;63:1725–1735.
Petrik József, Zani?-Grubisi? Tihana, Barisi? Karmela, et al. Apoptosis and oxidative stress induced by ochratoxin A in rat kidney. Archives of toxicology. 2003;77:685–693.
Luhe Anke, Hildebrand Heinz, Bach Ute, Dingermann Theodor, Ahr Hans-Jurgen J.. A new approach to studying ochratoxin A (OTA)-induced nephrotoxicity: expression profiling in vivo and in vitro employing cDNA microarrays. Toxicological sciences : an official journal of the Society of Toxicology. 2003;73:315–328.
Müller G., Burkert B., Rosner H., Köhler H.. Effects of the mycotoxin ochratoxin A and some of its metabolites on human kidney cell lines. Toxicology in vitro : an international journal published in association with BIBRA. 2003;17:441–448.
Sauvant C., Holzinger H., Gekle M.. Inhibition of the mitogen activated protein kinase ERK1/2 amplifies ochratoxin A toxicity in the proximal tubule of the kidney. Mycotoxin research. 2003;19:118–123.
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[expand title=”__Effects on Offspring” swaptitle=”__Hide Effects on Offspring”]
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[expand title=”__Presence in Milk” swaptitle=”__Hide Presence in Milk”]
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[expand title=”__Urinary & Bladder Effects” swaptitle=”__Hide Urinary & Bladder Effects”]
Gazinska Patrycja, Herman Diana, Gillett Cheryl, Pinder Sarah, Mantle Peter. Comparative immunohistochemical analysis of ochratoxin A tumourigenesis in rats and urinary tract carcinoma in humans; mechanistic significance of p-S6 ribosomal protein expression. Toxins. 2012;4:643–662.
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Kumar Rahul, Alam Shamshad, Chaudhari Bhushan P., et al. Ochratoxin A-induced cell proliferation and tumor promotion in mouse skin by activating the expression of cyclin-D1 and cyclooxygenase-2 through nuclear factor-kappa B and activator protein-1. Carcinogenesis. 2013;34:647–657.
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[expand title=”__Immune System Effects” swaptitle=”__Hide Immune System Effects”]
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Cui Jinfeng, Liu Jing, Wu Sha, et al. Oxidative DNA damage is involved in ochratoxin A induced G2 arrest through ataxia telangiectasia-mutated (ATM) pathways in human gastric epithelium GES-1 cells in vitro. Archives of toxicology. 2013.
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[expand title=”__Endocrine Effects” swaptitle=”__Hide Endocrine Effects”]
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[expand title=”__Effects on Bones and Skin” swaptitle=”__Effects on Bones and Skin”]
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[expand title=”__Respiratory Effects” swaptitle=”__Hide Respiratory Effects”]
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[expand title=”__Adipose Tissue Effects” swaptitle=”__Hide Adipose Tissue Effects”]
Lim Seyoung, Jang Hyun-Jun J., Kim Jung Kuk K., et al. Ochratoxin A inhibits adipogenesis through the extracellular signal-related kinases-peroxisome proliferator-activated receptor-? pathway in human adipose tissue-derived mesenchymal stem cells. Stem cells and development. 2011;20:415–426.
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[expand title=”__Endothelial Cell Effects” swaptitle=”__Hide Endothelial Cell Effects”]
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[expand title=”__Human Serum Albumin Effects” swaptitle=”__Hide Human Serum Albumin Effects”]
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[expand title=”__Genotoxic Effects” swaptitle=”__Hide Genotoxic Effects”]
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[expand title=”__Oxidative Stress & Glutathione” swaptitle=”__Hide Oxidative Stress & Glutathione”]
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[expand title=”__Toxicokinetics” swaptitle=”__Hide Toxicokinetics”]
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